Pilot Study to Predict Pharmacokinetics of a Therapeutic Gemcitabine Dose From a Microdose.

Van Nuland, M; Rosing, H; Thijssen, B; Burgers, J A; Huitema, A D R; Marchetti, S; Schellens, J H M; Beijnen, J H

Van Nuland, M; Rosing, H; Thijssen, B; Burgers, J A; Huitema, A D R; Marchetti, S; Schellens, J H M; Beijnen, J H.

Affiliation

Van Nuland M; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Rosing H; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Thijssen B; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Burgers JA; Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Huitema ADR; Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Marchetti S; Division of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Schellens JHM; Department of Clinical Pharmacy University Medical Center Utrecht, Utrecht University, the Netherlands.
Beijnen JH; Division of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Clin Pharmacol Drug Dev ; 9(8): 929-937, 2020 11.

Article in En | MEDLINE | ID: mdl-31970932

Subject(s)

Antimetabolites, Antineoplastic/pharmacokinetics; Chromatography, Liquid/methods; Deoxycytidine/analogs & derivatives; Dose-Response Relationship, Drug; Mass Spectrometry/instrumentation; Administration, Intravenous; Aged; Antimetabolites, Antineoplastic/administration & dosage; Antimetabolites, Antineoplastic/blood; Antimetabolites, Antineoplastic/therapeutic use; Area Under Curve; Carcinoma, Non-Small-Cell Lung/drug therapy; Deoxycytidine/administration & dosage; Deoxycytidine/blood; Deoxycytidine/pharmacokinetics; Deoxycytidine/therapeutic use; Female; Humans; Male; Mesothelioma/drug therapy; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Thymoma/drug therapy; Gemcitabine

Key words

Microdose; difluorodeoxyuracil; gemcitabine; linearity; phase 0; predictability

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mass Spectrometry / Chromatography, Liquid / Deoxycytidine / Dose-Response Relationship, Drug / Antimetabolites, Antineoplastic Type of study: Observational_studies / Prognostic_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Pharmacol Drug Dev Year: 2020 Document type: Article

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