New phenolic acids from the whole herb of Elephantopus scaber Linn. and their anti-inflammatory activity.
Nat Prod Res
; 35(21): 3667-3674, 2021 Nov.
Article
in En
| MEDLINE
| ID: mdl-32019347
ABSTRACT
Two new phenolic acids, ethyl 3,3',4,4'-tetrahydroxy-δ-truxinate (1), 3-O-p-coumaroyl-4-O-caffeoyl quinic acid methyl ester (2), together with three known compounds (3-5) were isolated from the whole plant of Elephantopus scaber Linn. The structures of the new compounds were elucidated using detailed spectroscopic analysis. Compound 3 was obtained and given its NMR data for the first time. All isolates were evaluated for their anti-inflammatory activity via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells, and 1, 4 and 5 showed a moderate inhibition with IC50 values ranging from 11.85 to 20.62 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asteraceae
Limits:
Animals
Language:
En
Journal:
Nat Prod Res
Year:
2021
Document type:
Article