Strain-level analysis of gut-resident pro-inflammatory viridans group Streptococci suppressed by long-term cotrimoxazole prophylaxis among HIV-positive children in Zimbabwe.

Gough, Ethan K; Bourke, Claire D; Berejena, Chipo; Shonhai, Annie; Bwakura-Dangarembizi, Mutsa; Prendergast, Andrew J; Manges, Amee R

Gough, Ethan K; Bourke, Claire D; Berejena, Chipo; Shonhai, Annie; Bwakura-Dangarembizi, Mutsa; Prendergast, Andrew J; Manges, Amee R.

Affiliation

Gough EK; Department of International Health, Division of Human Nutrition, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD, USA.
Bourke CD; Blizard Institute, Queen Mary University of London , London, UK.
Berejena C; Zvitambo Institute for Maternal and Child Health Research , Harare, Zimbabwe.
Shonhai A; College of Health Sciences, University of Zimbabwe , Harare, Zimbabwe.
Bwakura-Dangarembizi M; College of Health Sciences, University of Zimbabwe , Harare, Zimbabwe.
Prendergast AJ; College of Health Sciences, University of Zimbabwe , Harare, Zimbabwe.
Manges AR; Blizard Institute, Queen Mary University of London , London, UK.

Gut Microbes ; 11(4): 1104-1115, 2020 07 03.

Article in En | MEDLINE | ID: mdl-32024435

Subject(s)

Antibiotic Prophylaxis; Gastrointestinal Microbiome/drug effects; HIV Infections/microbiology; Streptococcus salivarius/drug effects; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use; Viridans Streptococci/drug effects; Anti-Bacterial Agents/therapeutic use; Anti-HIV Agents/therapeutic use; Child; Feces/microbiology; HIV Infections/drug therapy; Humans; Inflammation/microbiology; Inflammation/prevention & control; Intestines/immunology; Intestines/microbiology; Species Specificity; Streptococcus salivarius/classification; Streptococcus salivarius/physiology; Viridans Streptococci/classification; Viridans Streptococci/physiology; Zimbabwe

Key words

HIV; antimicrobial resistance; cotrimoxazole; gut health; immune modulation; inflammation; microbiota; septra; septrin

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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 / 3_ND Database: MEDLINE Main subject: HIV Infections / Trimethoprim, Sulfamethoxazole Drug Combination / Antibiotic Prophylaxis / Viridans Streptococci / Gastrointestinal Microbiome / Streptococcus salivarius Type of study: Clinical_trials / Guideline Limits: Child / Humans Country/Region as subject: Africa Language: En Journal: Gut Microbes Year: 2020 Document type: Article

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