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The small molecule BI-2852 induces a nonfunctional dimer of KRAS.
Tran, Timothy H; Alexander, Patrick; Dharmaiah, Srisathiyanarayanan; Agamasu, Constance; Nissley, Dwight V; McCormick, Frank; Esposito, Dominic; Simanshu, Dhirendra K; Stephen, Andrew G; Balius, Trent E.
Affiliation
  • Tran TH; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • Alexander P; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • Dharmaiah S; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • Agamasu C; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • Nissley DV; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • McCormick F; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • Esposito D; Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94158.
  • Simanshu DK; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • Stephen AG; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
  • Balius TE; National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Proc Natl Acad Sci U S A ; 117(7): 3363-3364, 2020 02 18.
Article in En | MEDLINE | ID: mdl-32047043
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) Language: En Journal: Proc Natl Acad Sci U S A Year: 2020 Document type: Article