Bioelution, Bioavailability, and Toxicity of Cobalt Compounds Correlate.

Danzeisen, Ruth; Williams, David Lee; Viegas, Vanessa; Dourson, Michael; Verberckmoes, Steven; Burzlaff, Arne

Danzeisen, Ruth; Williams, David Lee; Viegas, Vanessa; Dourson, Michael; Verberckmoes, Steven; Burzlaff, Arne.

Affiliation

Danzeisen R; Cobalt Institute, Guildford GU1 4AP, UK.
Williams DL; Williams Chemical Consultancy Limited, Dublin, Ireland.
Viegas V; Cobalt Institute, Guildford GU1 4AP, UK.
Dourson M; Toxicology Excellence for Risk Assessment, Cincinnati, Ohio 45102.
Verberckmoes S; Umicore - Corporate EHS, 1000 Brussels, Belgium.
Burzlaff A; EBRC Consulting GmbH, 30177 Hannover, Germany.

Toxicol Sci ; 174(2): 311-325, 2020 04 01.

Article in En | MEDLINE | ID: mdl-32058562

Subject(s)

Cobalt/toxicity; Oxides/toxicity; Administration, Oral; Animals; Biological Availability; Cobalt/administration & dosage; Cobalt/chemistry; Cobalt/pharmacokinetics; Female; Gastric Juice/chemistry; Injections, Intravenous; Intestinal Secretions/chemistry; Male; Oxides/administration & dosage; Oxides/chemistry; Oxides/pharmacokinetics; Rats, Sprague-Dawley; Risk Assessment; Solubility; Toxicokinetics

Key words

3Rs; bioaccessibility; grouping; inorganics(s); metal(s); read across

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxides / Cobalt Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Toxicol Sci Year: 2020 Document type: Article

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