Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner.

Hempel, C; Protze, J; Altun, E; Riebe, B; Piontek, A; Fromm, A; Lee, I M; Saleh, T; Günzel, D; Krause, G; Piontek, J

Hempel, C; Protze, J; Altun, E; Riebe, B; Piontek, A; Fromm, A; Lee, I M; Saleh, T; Günzel, D; Krause, G; Piontek, J.

Affiliation

Hempel C; Charité - Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Protze J; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin, Germany.
Altun E; Charité - Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Riebe B; Charité - Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Piontek A; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin, Germany.
Fromm A; Charité - Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Lee IM; Charité - Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Saleh T; Charité - Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Günzel D; Charité - Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany.
Krause G; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Straße 10, 13125 Berlin, Germany.
Piontek J; Charité - Universitätsmedizin Berlin, Institute of Clinical Physiology, Hindenburgdamm 30, 12203 Berlin, Germany. Electronic address: joerg.piontek@charite.de.

J Mol Biol ; 432(7): 2405-2427, 2020 03 27.

Article in En | MEDLINE | ID: mdl-32142789

Subject(s)

Claudin-3/chemistry; Claudins/chemistry; Protein Multimerization; Tight Junctions/chemistry; Animals; Cell Membrane Permeability; Claudin-3/genetics; Claudin-3/metabolism; Claudins/genetics; Claudins/metabolism; HEK293 Cells; Humans; Ion Channels; Mice; Mutation; Protein Conformation; Syndrome; Tight Junctions/metabolism

Key words

barrier; modelling; oligomerisation; paracellular permeability; pore

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tight Junctions / Protein Multimerization / Claudins / Claudin-3 Limits: Animals / Humans Language: En Journal: J Mol Biol Year: 2020 Document type: Article

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