Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review.

Brandt, Lærke J B; Barnkob, Mike B; Michaels, Yale S; Heiselberg, Julia; Barington, Torben

Brandt, Lærke J B; Barnkob, Mike B; Michaels, Yale S; Heiselberg, Julia; Barington, Torben.

Affiliation

Brandt LJB; Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Barnkob MB; Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Michaels YS; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
Heiselberg J; Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Barington T; Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.

Front Immunol ; 11: 326, 2020.

Article in En | MEDLINE | ID: mdl-32194561

Subject(s)

Cytokine Release Syndrome/prevention & control; Immunotherapy, Adoptive; T-Lymphocyte Subsets/immunology; Antigens, Neoplasm/immunology; CRISPR-Cas Systems; Cell Hypoxia; Cetuximab/pharmacology; Cetuximab/therapeutic use; Cytokine Release Syndrome/etiology; Cytokines/biosynthesis; Genes, Transgenic, Suicide; Humans; Immunotherapy, Adoptive/adverse effects; Immunotherapy, Adoptive/methods; Interleukin 1 Receptor Antagonist Protein/biosynthesis; Lymphocyte Activation; Protease Inhibitors/pharmacology; Protease Inhibitors/therapeutic use; Protein Binding; Protein Domains; Receptors, Antigen, T-Cell, alpha-beta/genetics; Receptors, Chimeric Antigen/genetics; Receptors, Chimeric Antigen/immunology; Rituximab/pharmacology; Rituximab/therapeutic use; T-Cell Antigen Receptor Specificity; T-Lymphocyte Subsets/drug effects; T-Lymphocyte Subsets/transplantation; Tetracycline/pharmacology; Transcription, Genetic/drug effects; Transfection; Tumor Microenvironment

Key words

T cell; cancer; cell therapy; chimeric antigen receptor; immunotherapy; regulation; synthetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy, Adoptive / T-Lymphocyte Subsets / Cytokine Release Syndrome Type of study: Etiology_studies Limits: Humans Language: En Journal: Front Immunol Year: 2020 Document type: Article

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