CD4+ T cell phenotypes in the pathogenesis of immune thrombocytopenia.
Cell Immunol
; 351: 104096, 2020 05.
Article
in En
| MEDLINE
| ID: mdl-32199587
ABSTRACT
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts due to enhanced platelet clearance and compromised production. Traditionally, ITP was regarded a B cell mediated disorder as anti-platelet antibodies are detected in most patients. The very nature of self-antigens, evident processes of isotype switching and the affinity maturation of anti-platelet antibodies indicate that B cells in order to mount anti-platelet immune response require assistance of auto-reactive CD4+ T cells. For a long time, ITP pathogenesis has been exclusively reviewed through the prism of the disturbed balance between Th1 and Th2 subsets of CD4+ T cells, however, more recently new subsets of these cells have been described including Th17, Th9, Th22, T follicular helper and regulatory T cells. In this paper, we review the current understanding of the role and immunological mechanisms by which CD4+ T cells contribute to the pathogenesis of ITP.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
CD4-Positive T-Lymphocytes
/
T-Lymphocyte Subsets
/
Purpura, Thrombocytopenic, Idiopathic
Type of study:
Etiology_studies
Limits:
Humans
Language:
En
Journal:
Cell Immunol
Year:
2020
Document type:
Article