UHRF1, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer.
Cancer Invest
; 38(4): 240-249, 2020 Apr.
Article
in En
| MEDLINE
| ID: mdl-32212938
We evaluated the value of UHRF1, a regulator of methylation, as a biomarker for lung cancer. UHRF1 is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that UHRF1 expression is correlated with worse survival in patients with AD but not in those with SQ. UHRF1 knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest that UHRF1 may server as a diagnostic marker for AD and SQ and as a prognostic marker for AD in lung cancer.
Key words
Full text:
1
Collection:
01-internacional
Health context:
6_ODS3_enfermedades_notrasmisibles
Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Biomarkers, Tumor
/
CCAAT-Enhancer-Binding Proteins
/
Ubiquitin-Protein Ligases
/
Adenocarcinoma of Lung
/
Lung Neoplasms
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Cancer Invest
Year:
2020
Document type:
Article