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The genomic landscape of undifferentiated embryonal sarcoma of the liver is typified by C19MC structural rearrangement and overexpression combined with TP53 mutation or loss.
Setty, Bhuvana A; Jinesh, Goodwin G; Arnold, Michael; Pettersson, Fredrik; Cheng, Chia-Ho; Cen, Ling; Yoder, Sean J; Teer, Jamie K; Flores, Elsa R; Reed, Damon R; Brohl, Andrew S.
Affiliation
  • Setty BA; Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, Ohio, United States of America.
  • Jinesh GG; Department of Pediatrics, The Ohio State University Wexner Medical Center Columbus, Ohio, United States of America.
  • Arnold M; Chemical Biology and Molecular Medicine Program, Moffitt Cancer Center, Florida, United States of America.
  • Pettersson F; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, United States of America.
  • Cheng CH; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.
  • Cen L; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
  • Yoder SJ; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
  • Teer JK; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
  • Flores ER; Molecular Genomics Core Facility, Moffitt Cancer Center, Tampa, Florida, United States of America.
  • Reed DR; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
  • Brohl AS; Department of Molecular Oncology, Moffitt Cancer Center, Tampa, Florida, United States of America.
PLoS Genet ; 16(4): e1008642, 2020 04.
Article in En | MEDLINE | ID: mdl-32310940
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma / Chromosomes, Human, Pair 19 / Gene Expression Regulation, Neoplastic / Tumor Suppressor Protein p53 / Neoplasms, Germ Cell and Embryonal / MicroRNAs / Chromosome Breakpoints / Liver Neoplasms / Mutation Limits: Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: PLoS Genet Year: 2020 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma / Chromosomes, Human, Pair 19 / Gene Expression Regulation, Neoplastic / Tumor Suppressor Protein p53 / Neoplasms, Germ Cell and Embryonal / MicroRNAs / Chromosome Breakpoints / Liver Neoplasms / Mutation Limits: Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: PLoS Genet Year: 2020 Document type: Article