Effect of low dose metronomic therapy on MCF-7 tumor cells growth and angiogenesis. Role of muscarinic acetylcholine receptors.

Salem, A R; Martínez Pulido, P; Sanchez, F; Sanchez, Y; Español, A J; Sales, M E

Salem, A R; Martínez Pulido, P; Sanchez, F; Sanchez, Y; Español, A J; Sales, M E.

Affiliation

Salem AR; Centro de Estudios Farmacológicos y Botánicos (CEFYBO)-CONICET, 2da Cátedra de Farmacología, Facultad de Medicina, UBA, Argentina.
Martínez Pulido P; Centro de Estudios Farmacológicos y Botánicos (CEFYBO)-CONICET, 2da Cátedra de Farmacología, Facultad de Medicina, UBA, Argentina.
Sanchez F; Centro de Estudios Farmacológicos y Botánicos (CEFYBO)-CONICET, 2da Cátedra de Farmacología, Facultad de Medicina, UBA, Argentina.
Sanchez Y; Centro de Estudios Farmacológicos y Botánicos (CEFYBO)-CONICET, 2da Cátedra de Farmacología, Facultad de Medicina, UBA, Argentina.
Español AJ; Centro de Estudios Farmacológicos y Botánicos (CEFYBO)-CONICET, 2da Cátedra de Farmacología, Facultad de Medicina, UBA, Argentina.
Sales ME; Centro de Estudios Farmacológicos y Botánicos (CEFYBO)-CONICET, 2da Cátedra de Farmacología, Facultad de Medicina, UBA, Argentina. Electronic address: malegazpio@yahoo.com.ar.

Int Immunopharmacol ; 84: 106514, 2020 Jul.

Article in En | MEDLINE | ID: mdl-32311671

Subject(s)

Antineoplastic Agents, Phytogenic/administration & dosage; Carbachol/administration & dosage; Cholinergic Agonists/administration & dosage; Mammary Neoplasms, Experimental/drug therapy; Neovascularization, Pathologic/drug therapy; Paclitaxel/administration & dosage; Receptors, Muscarinic/metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism; Administration, Metronomic; Animals; Cell Line; Cell Proliferation/drug effects; Cell Survival/drug effects; Drug Interactions; Female; Humans; Mammary Glands, Animal/blood supply; Mammary Glands, Animal/drug effects; Mammary Glands, Animal/metabolism; Mammary Glands, Animal/pathology; Mammary Neoplasms, Experimental/metabolism; Mammary Neoplasms, Experimental/pathology; Mice, Nude; Neovascularization, Pathologic/metabolism; Neovascularization, Pathologic/pathology

Key words

ABCG2; Angiogenesis; CD44(+)/CD24(−) cells; In vitro tumor growth; MCF-7 breast tumor cells; Metronomic therapy; Muscarinic receptors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbachol / Receptors, Muscarinic / Paclitaxel / Cholinergic Agonists / Mammary Neoplasms, Experimental / Neovascularization, Pathologic / Antineoplastic Agents, Phytogenic Limits: Animals / Female / Humans Language: En Journal: Int Immunopharmacol Year: 2020 Document type: Article

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