From Banding to BAM Files: Genomics Informs Diagnosis and Precision Medicine for Brain Tumors.
Surg Pathol Clin
; 13(2): 343-347, 2020 Jun.
Article
in En
| MEDLINE
| ID: mdl-32389271
ABSTRACT
Tumors of the central nervous system (CNS) have been historically classified according to their morphologic and immunohistochemical features. In 2016, updates to the classification of tumors of the CNS by the World Health Organization revolutionized this paradigm. For the first time, genomic findings, whether whole-arm chromosomal aberrations or single nucleotide variants, represent a necessary and critical component of diagnosis, contributing or superseding histologic findings. These updates stem from decades of technical innovation and genomic discovery. During this time, there has been a dramatic expansion and evolution in clinical genomic assays for these tumors, informing diagnosis and guiding therapeutic management.
Key words
Full text:
1
Collection:
01-internacional
Health context:
11_ODS3_cobertura_universal
/
2_ODS3
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Precision Medicine
/
Karyotyping
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Surg Pathol Clin
Year:
2020
Document type:
Article