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The safety and tolerability of epacadostat alone and in combination with pembrolizumab in patients with advanced solid tumors: results from a first-in-Japanese phase I study (KEYNOTE-434).
Doi, Toshihiko; Fujiwara, Yutaka; Shitara, Kohei; Shimizu, Toshio; Yonemori, Kan; Matsubara, Nobuaki; Ohno, Izumi; Kogawa, Takahiro; Naito, Yoichi; Leopold, Lance; Munteanu, Mihaela; Yatsuzuka, Naoyoshi; Han, Shi Rong; Samkari, Ayman; Yamamoto, Noboru.
Affiliation
  • Doi T; Department of Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa, Japan. tdoi@east.ncc.go.jp.
  • Fujiwara Y; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
  • Shitara K; Department of Respiratory Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
  • Shimizu T; Department of Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa, Japan.
  • Yonemori K; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
  • Matsubara N; Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.
  • Ohno I; Department of Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa, Japan.
  • Kogawa T; Department of Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa, Japan.
  • Naito Y; Department of Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa, Japan.
  • Leopold L; Department of Experimental Therapeutics, National Cancer Center Hospital East, Kashiwa, Japan.
  • Munteanu M; Incyte Corporation, Clinical Development, Wilmington, DE, USA.
  • Yatsuzuka N; Incyte Corporation, Clinical Development, Wilmington, DE, USA.
  • Han SR; MSD K.K. Oncology Science Unit, Tokyo, Japan.
  • Samkari A; MSD K.K. Oncology Science Unit, Tokyo, Japan.
  • Yamamoto N; Department of Clinical Oncology, Merck & Co., Inc., Kenilworth, NJ, USA.
Invest New Drugs ; 39(1): 152-162, 2021 02.
Article in En | MEDLINE | ID: mdl-32564277
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Sulfonamides / Antibodies, Monoclonal, Humanized / Neoplasms / Antineoplastic Agents Type of study: Clinical_trials / Prognostic_studies Limits: Aged / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Invest New Drugs Year: 2021 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Sulfonamides / Antibodies, Monoclonal, Humanized / Neoplasms / Antineoplastic Agents Type of study: Clinical_trials / Prognostic_studies Limits: Aged / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Invest New Drugs Year: 2021 Document type: Article