Transfer of pathological &#945;-synuclein from neurons to astrocytes via exosomes causes inflammatory responses after METH exposure.

Meng, Yunle; Ding, Jiuyang; Li, Chen; Fan, Haoliang; He, Yitong; Qiu, Pingming

Transfer of pathological α-synuclein from neurons to astrocytes via exosomes causes inflammatory responses after METH exposure.

Meng, Yunle; Ding, Jiuyang; Li, Chen; Fan, Haoliang; He, Yitong; Qiu, Pingming.

Affiliation

Meng Y; School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Ding J; School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Li C; School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Fan H; School of Forensic Medicine, Southern Medical University, Guangzhou, China; School of Basic Medicine and Life Science, Hainan Medical University, Haikou, China.
He Y; School of Forensic Medicine, Southern Medical University, Guangzhou, China.
Qiu P; School of Forensic Medicine, Southern Medical University, Guangzhou, China. Electronic address: qiupmfy@126.com.

Toxicol Lett ; 331: 188-199, 2020 Oct 01.

Article in En | MEDLINE | ID: mdl-32569805

Subject(s)

Astrocytes/drug effects; Central Nervous System Stimulants/toxicity; Exosomes/metabolism; Methamphetamine/toxicity; Neurons/drug effects; Neurotoxicity Syndromes/metabolism; alpha-Synuclein/metabolism; Animals; Astrocytes/immunology; Astrocytes/metabolism; Cell Line, Tumor; Coculture Techniques; Cytokines/metabolism; Hippocampus/cytology; Humans; Injections, Intraperitoneal; Male; Mice, Inbred C57BL; Neurons/immunology; Neurons/metabolism; Neurotoxicity Syndromes/immunology; Nuclear Receptor Subfamily 4, Group A, Member 2/genetics; Primary Cell Culture; Synucleinopathies/immunology; Synucleinopathies/metabolism

Key words

Exosomes; Inflammation; Methamphetamine; Nurr1; α-synuclein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Astrocytes / Neurotoxicity Syndromes / Alpha-Synuclein / Exosomes / Central Nervous System Stimulants / Methamphetamine / Neurons Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Toxicol Lett Year: 2020 Document type: Article

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