Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression.

Wang, Lei; Li, Ying-Shuang; Yu, Lu-Gang; Zhang, Xin-Ke; Zhao, Lin; Gong, Fu-Lian; Yang, Xiao-Xia; Guo, Xiu-Li

Wang, Lei; Li, Ying-Shuang; Yu, Lu-Gang; Zhang, Xin-Ke; Zhao, Lin; Gong, Fu-Lian; Yang, Xiao-Xia; Guo, Xiu-Li.

Affiliation

Wang L; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Li YS; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Yu LG; Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Zhang XK; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Zhao L; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Gong FL; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; Department of Pharmacy, Tianjin Children's Hospital, Tianjin, China.
Yang XX; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Guo XL; Department of Pharmacology, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China. Electronic address: guoxl@sdu.edu.cn.

Biochem Pharmacol ; 178: 114113, 2020 08.

Article in En | MEDLINE | ID: mdl-32579956

Subject(s)

Adenocarcinoma/drug therapy; Bevacizumab/pharmacology; Breast Neoplasms/drug therapy; Galectin 3/antagonists & inhibitors; Gene Expression Regulation, Neoplastic; Hypoxia/drug therapy; Mammary Neoplasms, Experimental/drug therapy; Adenocarcinoma/genetics; Adenocarcinoma/metabolism; Adenocarcinoma/pathology; Animals; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Line, Tumor; Cell Movement/drug effects; Cell Proliferation/drug effects; Clodronic Acid/pharmacology; Coculture Techniques; Disease Progression; Female; Galectin 3/genetics; Galectin 3/metabolism; Humans; Hypoxia/genetics; Hypoxia/metabolism; Hypoxia/pathology; Lymphatic Metastasis; Macrophages/drug effects; Macrophages/metabolism; Macrophages/pathology; Mammary Neoplasms, Experimental/genetics; Mammary Neoplasms, Experimental/metabolism; Mammary Neoplasms, Experimental/pathology; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B/genetics; NF-kappa B/metabolism; Neovascularization, Pathologic; Pectins/pharmacology; Signal Transduction; Sorafenib/pharmacology

Key words

Bevacizumab; Galectin-3; Hypoxia; Modified citrus pectin; TAMs

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Adenocarcinoma / Gene Expression Regulation, Neoplastic / Galectin 3 / Bevacizumab / Mammary Neoplasms, Experimental / Hypoxia Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Biochem Pharmacol Year: 2020 Document type: Article

Fulltext

XML

PubMed Links

Search on Google