Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages.

Thorpe, P E; Wallace, P M; Knowles, P P; Relf, M G; Brown, A N; Watson, G J; Blakey, D C; Newell, D R

Thorpe, P E; Wallace, P M; Knowles, P P; Relf, M G; Brown, A N; Watson, G J; Blakey, D C; Newell, D R.

Affiliation

Thorpe PE; Drug Targeting Laboratory, Imperial Cancer Research Fund, London, England.

Cancer Res ; 48(22): 6396-403, 1988 Nov 15.

Article in En | MEDLINE | ID: mdl-3263186

Subject(s)

Antineoplastic Agents/pharmacology; Immunotoxins/pharmacology; Ricin/pharmacology; Animals; Cell Survival/drug effects; Drug Stability; Female; Glycosylation; Immunotoxins/metabolism; Isoantibodies/immunology; Lethal Dose 50; Lymphoma/pathology; Lymphoma/therapy; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Ricin / Immunotoxins / Antineoplastic Agents Limits: Animals Language: En Journal: Cancer Res Year: 1988 Document type: Article

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