Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry.

Angel, Peggi M; Spruill, Laura; Jefferson, Melanie; Bethard, Jennifer R; Ball, Lauren E; Hughes-Halbert, Chanita; Drake, Richard R

Angel, Peggi M; Spruill, Laura; Jefferson, Melanie; Bethard, Jennifer R; Ball, Lauren E; Hughes-Halbert, Chanita; Drake, Richard R.

Affiliation

Angel PM; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Proteomics Center, Medical University of South Carolina, Charleston, South Carolina.
Spruill L; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
Jefferson M; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.
Bethard JR; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Proteomics Center, Medical University of South Carolina, Charleston, South Carolina.
Ball LE; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Proteomics Center, Medical University of South Carolina, Charleston, South Carolina.
Hughes-Halbert C; Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.
Drake RR; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Proteomics Center, Medical University of South Carolina, Charleston, South Carolina.

Prostate ; 80(13): 1071-1086, 2020 09.

Article in En | MEDLINE | ID: mdl-32687633

Subject(s)

Collagen/metabolism; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Protein Processing, Post-Translational; Aged; Amino Acid Sequence; Autoantigens; Collagen Type I/metabolism; Collagen Type I, alpha 1 Chain; Collagen Type III/metabolism; Collagen Type IV/metabolism; Collagen Type VIII/metabolism; Disease Progression; Fibrillar Collagens/metabolism; Humans; Hydroxylation; Male; Middle Aged; Neoplasm Proteins/metabolism; Non-Fibrillar Collagens; Proline/metabolism; Prostate/metabolism; Prostatectomy; Prostatic Neoplasms/diagnostic imaging; Proteomics/methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods; Spectroscopy, Fourier Transform Infrared/methods; Collagen Type XVII

Key words

MALDI imaging mass spectrometry; collagen; formalin-fixed; imaging mass spectrometry; paraffin-embedded tissue imaging; peptide imaging; proline hydroxylation; prostate adenocarcinoma; prostate cancer; proteomics; tissue imaging

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Protein Processing, Post-Translational / Collagen Type of study: Prognostic_studies Limits: Aged / Humans / Male / Middle aged Language: En Journal: Prostate Year: 2020 Document type: Article

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