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Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity.
Borodovsky, Alexandra; Barbon, Christine M; Wang, Yanjun; Ye, Minwei; Prickett, Laura; Chandra, Dinesh; Shaw, Joseph; Deng, Nanhua; Sachsenmeier, Kris; Clarke, James D; Linghu, Bolan; Brown, Giles A; Brown, James; Congreve, Miles; Cheng, Robert Ky; Dore, Andrew S; Hurrell, Edward; Shao, Wenlin; Woessner, Richard; Reimer, Corinne; Drew, Lisa; Fawell, Stephen; Schuller, Alwin G; Mele, Deanna A.
Affiliation
  • Borodovsky A; Discovery Biology, Nurix Inc, San Francisco, California, USA.
  • Barbon CM; Preclinical Biology, Bluefin Biomedicine, Beverly, Massachusetts, USA.
  • Wang Y; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Ye M; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Prickett L; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Chandra D; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Shaw J; Discovery Sciences, AstraZeneca PLC, Cambridge, Cambridgeshire, UK.
  • Deng N; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Sachsenmeier K; Translational Medicine, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Clarke JD; Drug Metabolism and Pharamcokinetics, AstraZeneca, Cambridge, Cambridgeshire, UK.
  • Linghu B; Translational Medicine, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Brown GA; Discovery, Omass Technologies Ltd, Oxford, United Kingdom.
  • Brown J; Heptares Therapeutics, Welwyn Garden City, California, USA.
  • Congreve M; Heptares Therapeutics, Welwyn Garden City, California, USA.
  • Cheng RK; X-ray Crystallography, LeadXPro, Villigen, Switzerland.
  • Dore AS; Heptares Therapeutics, Welwyn Garden City, California, USA.
  • Hurrell E; Heptares Therapeutics, Welwyn Garden City, California, USA.
  • Shao W; Oncology, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Woessner R; Pharmacology, Blueprint Medicines, Cambridge, Massachusetts, USA.
  • Reimer C; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Drew L; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Fawell S; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Schuller AG; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
  • Mele DA; Bioscience, AstraZeneca R&D Boston, Waltham, Massachusetts, USA deanna.mele@astrazeneca.com.
J Immunother Cancer ; 8(2)2020 07.
Article in En | MEDLINE | ID: mdl-32727810
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Antigens, CD / Integrin alpha Chains / Receptor, Adenosine A2A / Antineoplastic Agents, Immunological / Neoplasms Limits: Female / Humans / Male Language: En Journal: J Immunother Cancer Year: 2020 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Antigens, CD / Integrin alpha Chains / Receptor, Adenosine A2A / Antineoplastic Agents, Immunological / Neoplasms Limits: Female / Humans / Male Language: En Journal: J Immunother Cancer Year: 2020 Document type: Article