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Case-fatality From Orally-transmitted Acute Chagas Disease: A Systematic Review and Meta-analysis.
Bruneto, Eduardo G; Fernandes-Silva, Miguel M; Toledo-Cornell, Cristina; Martins, Silvia; Ferreira, João M B; Corrêa, Valeria R; da Costa, Joicely M; Pinto, Ana Yecê das N; de Souza, Dilma do S M; Pinto, Maria Carmelinda G; Neto, José Albuquerque de F; Ramos, Alberto N; Maguire, James H; Silvestre, Odilson M.
Affiliation
  • Bruneto EG; Federal University of Acre, Rio Branco, Brazil.
  • Fernandes-Silva MM; Federal University of Parana, Curitiba, Brazil.
  • Toledo-Cornell C; Lumni Tribal Health Center Elson S. Floyd College of Medicine, Bellingham, Washington, USA.
  • Martins S; University of Pernambuco, Recife, Brazil.
  • Ferreira JMB; University of Amazonas, Manaus, Brazil.
  • Corrêa VR; University of Tocantins, Palmas, Brazil.
  • da Costa JM; Federal University of Acre, Rio Branco, Brazil.
  • Pinto AYDN; Instituto Evandro Chagas/ Ministério da Saúde do Brasil, Belém, Brazil.
  • de Souza DDSM; Medical School of the Federal University of Pará, Belém, Brazil.
  • Pinto MCG; Secretary of Health of the State of Acre, Rio Branco, Brazil.
  • Neto JAF; Federal University of Maranhão, Sao Luis, Brazil.
  • Ramos AN; Federal University of Ceará, Fortaleza, Brazil.
  • Maguire JH; Division of Infectious Disease, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Silvestre OM; Federal University of Acre, Rio Branco, Brazil.
Clin Infect Dis ; 72(6): 1084-1092, 2021 03 15.
Article in En | MEDLINE | ID: mdl-32772104
ABSTRACT
Orally-transmitted acute Chagas disease (CD) is emerging as an important public health problem. The prognosis of acute infection following oral transmission is unknown. The aim of this study was to analyze and summarize data on orally-transmitted acute CD. We searched for publications from 1968 to 31 January 2018. We included studies and unpublished data from government sources that reported patients with acute orally-transmitted CD. We identified 41 papers and we added 932 unpublished cases. In all, our study covered 2470 cases and occurrence of 97 deaths. Our meta-analysis estimated that the case-fatality rate was 1.0% (95% CI 0.0-4.0%). Lethality rates have declined over time (P = .02). In conclusion, orally-transmitted acute CD has considerable lethality in the first year after infection. The lethality in symptomatic cases is similar to that from other routes of infection. The lethality rate of orally-acquired disease has declined over the years.
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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 3_ND / 4_TD Database: MEDLINE Main subject: Chagas Disease Type of study: Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Clin Infect Dis Year: 2021 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 3_ND / 4_TD Database: MEDLINE Main subject: Chagas Disease Type of study: Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Clin Infect Dis Year: 2021 Document type: Article