Case-fatality From Orally-transmitted Acute Chagas Disease: A Systematic Review and Meta-analysis.
Clin Infect Dis
; 72(6): 1084-1092, 2021 03 15.
Article
in En
| MEDLINE
| ID: mdl-32772104
ABSTRACT
Orally-transmitted acute Chagas disease (CD) is emerging as an important public health problem. The prognosis of acute infection following oral transmission is unknown. The aim of this study was to analyze and summarize data on orally-transmitted acute CD. We searched for publications from 1968 to 31 January 2018. We included studies and unpublished data from government sources that reported patients with acute orally-transmitted CD. We identified 41 papers and we added 932 unpublished cases. In all, our study covered 2470 cases and occurrence of 97 deaths. Our meta-analysis estimated that the case-fatality rate was 1.0% (95% CI 0.0-4.0%). Lethality rates have declined over time (Pâ
=â
.02). In conclusion, orally-transmitted acute CD has considerable lethality in the first year after infection. The lethality in symptomatic cases is similar to that from other routes of infection. The lethality rate of orally-acquired disease has declined over the years.
Key words
Full text:
1
Collection:
01-internacional
Health context:
2_ODS3
/
3_ND
/
4_TD
Database:
MEDLINE
Main subject:
Chagas Disease
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Clin Infect Dis
Year:
2021
Document type:
Article