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Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes.
O'Donovan, Shauna D; Driessens, Kurt; Lopatta, Daniel; Wimmenauer, Florian; Lukas, Alexander; Neeven, Jelmer; Stumm, Tobias; Smirnov, Evgueni; Lenz, Michael; Ertaylan, Gokhan; Jennen, Danyel G J; van Riel, Natal A W; Cavill, Rachel; Peeters, Ralf L M; de Kok, Theo M C M.
Affiliation
  • O'Donovan SD; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.
  • Driessens K; Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.
  • Lopatta D; Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands.
  • Wimmenauer F; Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands.
  • Lukas A; Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands.
  • Neeven J; Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands.
  • Stumm T; Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands.
  • Smirnov E; Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands.
  • Lenz M; Dept. of Data Science and Knowledge Engineering, Maastricht University, Maastricht, The Netherlands.
  • Ertaylan G; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.
  • Jennen DGJ; Institute of Organismic and Molecular Evolution, Johannes Gutenberg University Mainz, Mainz, Germany.
  • van Riel NAW; Preventive Cardiology and Preventative Medicine-Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
  • Cavill R; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.
  • Peeters RLM; Flemish Institute for Technological Research (VITO), Mol, Belgium.
  • de Kok TMCM; Dept. of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
PLoS One ; 15(8): e0236392, 2020.
Article in En | MEDLINE | ID: mdl-32780735

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Machine Learning / Deep Learning Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Year: 2020 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Machine Learning / Deep Learning Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Year: 2020 Document type: Article