Aminoglycoside antibiotics can inhibit or activate twister ribozyme cleavage.

Zhang, Jun; Liu, Getong; Sun, Wenxia; Chen, Dongrong; Murchie, Alastair I H

Zhang, Jun; Liu, Getong; Sun, Wenxia; Chen, Dongrong; Murchie, Alastair I H.

Affiliation

Zhang J; Fudan University Pudong Medical Center, and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Liu G; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Sun W; Fudan University Pudong Medical Center, and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Chen D; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Murchie AIH; Fudan University Pudong Medical Center, and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

FEBS J ; 288(5): 1586-1598, 2021 03.

Article in En | MEDLINE | ID: mdl-32790122

Subject(s)

Anti-Bacterial Agents/pharmacology; Paromomycin/pharmacology; RNA, Catalytic/genetics; Sisomicin/pharmacology; Animals; Base Pairing; Base Sequence; Biocatalysis; Catalytic Domain; Kinetics; Models, Molecular; Nucleic Acid Conformation/drug effects; Oligoribonucleotides/genetics; Oligoribonucleotides/metabolism; RNA, Catalytic/agonists; RNA, Catalytic/antagonists & inhibitors; RNA, Catalytic/metabolism; Wasps/chemistry; Wasps/metabolism

Key words

aminoglycoside antibiotics; inhibition of ribozyme activity; stimulation of ribozyme activity; twister ribozyme

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paromomycin / Sisomicin / RNA, Catalytic / Anti-Bacterial Agents Limits: Animals Language: En Journal: FEBS J Year: 2021 Document type: Article

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