Binding mechanisms of therapeutic antibodies to human CD20.

Kumar, Anand; Planchais, Cyril; Fronzes, Rémi; Mouquet, Hugo; Reyes, Nicolas

Kumar, Anand; Planchais, Cyril; Fronzes, Rémi; Mouquet, Hugo; Reyes, Nicolas.

Affiliation

Kumar A; Membrane Protein Mechanisms Unit, Institut Pasteur, 75015 Paris, France.
Planchais C; Membrane Protein Mechanisms Group, European Institute of Chemistry and Biology, University of Bordeaux, 33607 Pessac, France.
Fronzes R; CNRS UMR 5234 Fundamental Microbiology and Pathogenicity, Bordeaux, France.
Mouquet H; Laboratory of Humoral Immunology, Department of Immunology, Institut Pasteur, Paris, France.
Reyes N; INSERM U1222, Paris, France.

Science ; 369(6505): 793-799, 2020 08 14.

Article in En | MEDLINE | ID: mdl-32792392

Subject(s)

Antibodies, Monoclonal, Humanized/chemistry; Antigen-Antibody Complex/chemistry; Antigens, CD20/chemistry; Antineoplastic Agents/chemistry; Immunotherapy; Lymphoma, B-Cell/therapy; Rituximab/chemistry; Antibodies, Monoclonal, Humanized/immunology; Antibodies, Monoclonal, Humanized/therapeutic use; Antigen-Antibody Complex/immunology; Antigens, CD20/immunology; Antineoplastic Agents/immunology; B-Lymphocytes/immunology; Complement Activation; Cryoelectron Microscopy; Humans; Immunoglobulin Fab Fragments/chemistry; Immunoglobulin Fab Fragments/immunology; Protein Binding; Protein Conformation; Rituximab/immunology; Rituximab/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphoma, B-Cell / Antigens, CD20 / Antibodies, Monoclonal, Humanized / Rituximab / Immunotherapy / Antigen-Antibody Complex / Antineoplastic Agents Limits: Humans Language: En Journal: Science Year: 2020 Document type: Article

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