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Evaluation of biochemical and hematological parameters in adults with Down syndrome.
de Gonzalo-Calvo, David; Barroeta, Isabel; Nan, Madalina Nicoleta; Rives, José; Garzón, Diana; Carmona-Iragui, María; Benejam, Bessy; Videla, Laura; Fernández, Susana; Altuna, Miren; Valldeneu, Sílvia; Blesa, Rafael; Lleó, Alberto; Blanco-Vaca, Francisco; Fortea, Juan; Tondo, Mireia.
Affiliation
  • de Gonzalo-Calvo D; Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
  • Barroeta I; Institute of Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain.
  • Nan MN; Translational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
  • Rives J; Sant Pau Memory Unit, Department of Neurology, Hospital de La Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Garzón D; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  • Carmona-Iragui M; Department of Biochemistry, Hospital de La Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, C/Sant Quintí 89, 08041, Barcelona, Spain.
  • Benejam B; Department of Biochemistry, Hospital de La Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, C/Sant Quintí 89, 08041, Barcelona, Spain.
  • Videla L; Sant Pau Memory Unit, Department of Neurology, Hospital de La Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Fernández S; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  • Altuna M; Sant Pau Memory Unit, Department of Neurology, Hospital de La Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Valldeneu S; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  • Blesa R; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain.
  • Lleó A; Sant Pau Memory Unit, Department of Neurology, Hospital de La Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Blanco-Vaca F; Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
  • Fortea J; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain.
  • Tondo M; Sant Pau Memory Unit, Department of Neurology, Hospital de La Santa Creu i Sant Pau, Biomedical Research Institute (IIB) Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Sci Rep ; 10(1): 13755, 2020 08 13.
Article in En | MEDLINE | ID: mdl-32792619
Down syndrome (DS) is the most common worldwide cause of intellectual disability of genetic origin and the most common chromosomal disorder affecting live-born infants. In addition to intellectual disability, individuals with DS have other comorbidities and complex medical conditions. The increase in the life expectancy of patients with DS requires expanding the knowledge about their clinical characteristics and related laboratory parameters. Several studies exploring laboratory tests in DS patients exist, but their focus is limited to specific areas of metabolism. Therefore, our main goal was to describe the biochemical and hematological findings in a DS cohort and to compare the values to those of a control population. A total of 248 DS individuals and 84 control subjects were enrolled. DS individuals had a higher frequency of several clinical conditions compared to control individuals and presented with significant differences with respect to the controls in both biochemical and hematological parameters. We found age- and sex-related differences in several of the parameters. A good understanding of the differences in our cohort might be of aid in the clinical follow-up of adults with DS, especially considering that the lifespan of DS individuals may reach 60 years of age in developed countries.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Chemical Analysis / Biomarkers / Down Syndrome / Intellectual Disability Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Sci Rep Year: 2020 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Chemical Analysis / Biomarkers / Down Syndrome / Intellectual Disability Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Sci Rep Year: 2020 Document type: Article