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Lower CH50 as a predictor for intractable or recurrent lupus enteritis: A retrospective observational study.
Yoshida, Yusuke; Omoto, Takuji; Kohno, Hiroki; Tokunaga, Tadahiro; Kuranobu, Tatsuomi; Yukawa, Kazutoshi; Watanabe, Hirofumi; Oi, Katsuhiro; Sugimoto, Tomohiro; Mokuda, Sho; Nojima, Takaki; Hirata, Shintaro; Sugiyama, Eiji.
Affiliation
  • Yoshida Y; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Omoto T; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Kohno H; Department of Rheumatology, Hiroshima Prefectural Hospital, Hiroshima, Japan.
  • Tokunaga T; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Kuranobu T; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Yukawa K; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Watanabe H; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Oi K; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Sugimoto T; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Mokuda S; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Nojima T; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Hirata S; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
  • Sugiyama E; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan.
Mod Rheumatol ; 31(3): 643-648, 2021 May.
Article in En | MEDLINE | ID: mdl-32815450
OBJECTIVES: Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE. METHODS: We consecutively registered patients diagnosed with LE between January 2009 and October 2019, and retrospectively compared their clinical characteristics based on whether they had good or poor responses to treatment. RESULTS: A total of 13 patients (17 episodes) were included. The median age was 41 years, and 12 patients were female. A comparison of clinical characteristics between groups revealed similar computed tomography (CT) findings. However, serum CH50 levels were significantly lower in the poor response group (median [interquartile ranges (IQR)]; 29.2 [25.3-46.9] U/mL vs 19.3 [7.8-24.0] U/mL, p = .0095). More patients in the poor response group had higher titers of anti-cardiolipin ß2-glycoprotein I antibody (anti-CL ß2GPI Ab) and were started on glucocorticoids (GCs) at moderate doses. In multivariable analysis, serum CH50 level was independently associated with poor response to induction therapy. CONCLUSION: Lower levels of CH50 at the time of initial treatment predicted inadequate treatment response in patients with LE.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement Hemolytic Activity Assay / Enteritis / Lupus Erythematosus, Systemic Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Mod Rheumatol Year: 2021 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement Hemolytic Activity Assay / Enteritis / Lupus Erythematosus, Systemic Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Mod Rheumatol Year: 2021 Document type: Article