RNA-seq analysis of gene expression profiles in isolated stria vascularis from wild-type and Alport mice reveals key pathways underling Alport strial pathogenesis.

Dufek, Brianna; Meehan, Daniel T; Delimont, Duane; Wilhelm, Kevin; Samuelson, Gina; Coenen, Ross; Madison, Jacob; Doyle, Edward; Smyth, Brendan; Phillips, Grady; Gratton, Michael Anne; Cosgrove, Dominic

Dufek, Brianna; Meehan, Daniel T; Delimont, Duane; Wilhelm, Kevin; Samuelson, Gina; Coenen, Ross; Madison, Jacob; Doyle, Edward; Smyth, Brendan; Phillips, Grady; Gratton, Michael Anne; Cosgrove, Dominic.

Affiliation

Dufek B; Boys Town National Research Hospital, Omaha, NE, United States of America.
Meehan DT; Boys Town National Research Hospital, Omaha, NE, United States of America.
Delimont D; Boys Town National Research Hospital, Omaha, NE, United States of America.
Wilhelm K; Boys Town National Research Hospital, Omaha, NE, United States of America.
Samuelson G; Boys Town National Research Hospital, Omaha, NE, United States of America.
Coenen R; Boys Town National Research Hospital, Omaha, NE, United States of America.
Madison J; Boys Town National Research Hospital, Omaha, NE, United States of America.
Doyle E; Department of Otolaryngology, Wake Forest School of Medicine, Washington University, Saint Louis, MO, United States of America.
Smyth B; Department of Otolaryngology, Wake Forest School of Medicine, Washington University, Saint Louis, MO, United States of America.
Phillips G; Department of Otolaryngology, Wake Forest School of Medicine, Washington University, Saint Louis, MO, United States of America.
Gratton MA; Department of Otolaryngology, Wake Forest School of Medicine, Washington University, Saint Louis, MO, United States of America.
Cosgrove D; Boys Town National Research Hospital, Omaha, NE, United States of America.

PLoS One ; 15(8): e0237907, 2020.

Article in En | MEDLINE | ID: mdl-32822386

Subject(s)

Gene Expression Regulation/genetics; Hearing Loss, Noise-Induced/metabolism; Nephritis, Hereditary/metabolism; Stria Vascularis/metabolism; Animals; Autoantigens/genetics; Autoantigens/metabolism; Basement Membrane/metabolism; Chemokines/genetics; Chemokines/metabolism; Collagen Type IV/genetics; Collagen Type IV/metabolism; Cytokines/genetics; Cytokines/metabolism; Disease Models, Animal; Down-Regulation; Extracellular Matrix/metabolism; Female; Glucose/genetics; Glucose/metabolism; Hearing Loss, Noise-Induced/genetics; Inflammation/genetics; Inflammation/metabolism; Inflammation/pathology; Male; Mice; Nephritis, Hereditary/genetics; Nephritis, Hereditary/pathology; RNA-Seq; Signal Transduction/genetics; Stria Vascularis/pathology; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptome/genetics; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stria Vascularis / Gene Expression Regulation / Hearing Loss, Noise-Induced / Nephritis, Hereditary Type of study: Etiology_studies / Prognostic_studies Language: En Journal: PLoS One Year: 2020 Document type: Article

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