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Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos.
Naert, Thomas; Tulkens, Dieter; Edwards, Nicole A; Carron, Marjolein; Shaidani, Nikko-Ideen; Wlizla, Marcin; Boel, Annekatrien; Demuynck, Suzan; Horb, Marko E; Coucke, Paul; Willaert, Andy; Zorn, Aaron M; Vleminckx, Kris.
Affiliation
  • Naert T; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium.
  • Tulkens D; Cancer Research Institute Ghent, Ghent, Belgium.
  • Edwards NA; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium.
  • Carron M; Cancer Research Institute Ghent, Ghent, Belgium.
  • Shaidani NI; Division of Developmental Biology, Perinatal Institute, and Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital, Cincinnati, USA.
  • Wlizla M; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium.
  • Boel A; Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Demuynck S; National Xenopus Resource and Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
  • Horb ME; National Xenopus Resource and Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
  • Coucke P; Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  • Willaert A; Department of Biomedical Molecular Biology, Ghent University, Technologiepark 71, 9052, Ghent (Zwijnaarde), Belgium.
  • Zorn AM; Cancer Research Institute Ghent, Ghent, Belgium.
  • Vleminckx K; National Xenopus Resource and Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
Sci Rep ; 10(1): 14662, 2020 09 04.
Article in En | MEDLINE | ID: mdl-32887910
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xenopus laevis / Zebrafish / Penetrance / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2020 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xenopus laevis / Zebrafish / Penetrance / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2020 Document type: Article