Your browser doesn't support javascript.
loading
Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model.
Alvarez-Fischer, D; Vernik, T; Vulinovic, F; Herrmann, A; Westenberger, A; Klein, C.
Affiliation
  • Alvarez-Fischer D; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Psychiatry, University Hospital Schleswig-Holstein, Campus Lübeck, Germany. Electronic address: daniel.alvarez@neuro.uni-luebeck.de.
  • Vernik T; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany. Electronic address: tamara.vernik@uk-erlangen.de.
  • Vulinovic F; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address: franca.vulinovic@neuro.uni-luebeck.de.
  • Herrmann A; Department of Psychology, University of Lübeck, Germany. Electronic address: anne.herrmann@uni-luebeck.de.
  • Westenberger A; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address: ana.westenberger@neuro.uni-luebeck.de.
  • Klein C; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address: christine.klein@neuro.uni-luebeck.de.
Parkinsonism Relat Disord ; 79: 88-90, 2020 10.
Article in En | MEDLINE | ID: mdl-32906083
ABSTRACT
Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / MPTP Poisoning / Epigenesis, Genetic Limits: Animals Language: En Journal: Parkinsonism Relat Disord Year: 2020 Document type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / MPTP Poisoning / Epigenesis, Genetic Limits: Animals Language: En Journal: Parkinsonism Relat Disord Year: 2020 Document type: Article