Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study.
Nanomedicine (Lond)
; 15(25): 2433-2445, 2020 10.
Article
in En
| MEDLINE
| ID: mdl-32914695
ABSTRACT
Aim:
To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging. Materials &methods:
Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with their in vitro cytotoxicity assessed, followed by imaging assessments.Results:
The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion:
We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Magnetite Nanoparticles
/
Gold
Limits:
Humans
Language:
En
Journal:
Nanomedicine (Lond)
Year:
2020
Document type:
Article