Tiron protects against nicotine-induced lung and liver injury through antioxidant and anti-inflammatory actions in rats in vivo.

Khaled, Shimaa; Makled, Mirhan N; Nader, Manar A

Khaled, Shimaa; Makled, Mirhan N; Nader, Manar A.

Affiliation

Khaled S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Horus University, Egypt. Electronic address: shimaa_khaled95@yahoo.com.
Makled MN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Nader MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Life Sci ; 260: 118426, 2020 Nov 01.

Article in En | MEDLINE | ID: mdl-32937159

Subject(s)

1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt/pharmacology; Antioxidants/pharmacology; Chemical and Drug Induced Liver Injury/prevention & control; Lung Injury/prevention & control; Nicotine/toxicity; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Body Weight/drug effects; Bronchoalveolar Lavage Fluid/chemistry; Cell Count; Chemical and Drug Induced Liver Injury/etiology; Chemical and Drug Induced Liver Injury/mortality; Chemical and Drug Induced Liver Injury/pathology; Enzymes/blood; L-Lactate Dehydrogenase/metabolism; Lipids/blood; Lung Injury/chemically induced; Lung Injury/mortality; Lung Injury/pathology; Male; NADPH Oxidase 1/blood; NADPH Oxidase 1/metabolism; NF-kappa B/blood; NF-kappa B/metabolism; Nitric Oxide Synthase Type II/metabolism; Protective Agents/pharmacology; Rats, Sprague-Dawley

Key words

NF-κB; Nicotine; Nrf2; Oxidative stress; Tiron; iNOS

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt / Lung Injury / Chemical and Drug Induced Liver Injury / Nicotine / Antioxidants Type of study: Etiology_studies Limits: Animals Language: En Journal: Life Sci Year: 2020 Document type: Article

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