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A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity.
Pedersen, Henrik; Jensen, Rasmus K; Jensen, Jens Magnus B; Fox, Rachel; Pedersen, Dennis V; Olesen, Heidi G; Hansen, Annette G; Christiansen, Dorte; Mazarakis, Sofia M M; Lojek, Neal; Hansen, Pernille; Gadeberg, Trine A F; Zarantonello, Alessandra; Laursen, Nick S; Mollnes, Tom Eirik; Johnson, Matthew B; Stevens, Beth; Thiel, Steffen; Andersen, Gregers R.
Affiliation
  • Pedersen H; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Jensen RK; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Jensen JMB; Department of Clinical Immunology, DK-8200 Skejby, Denmark.
  • Fox R; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
  • Pedersen DV; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Olesen HG; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Hansen AG; Department of Biomedicine, Aarhus University, DK-8000 Aarhus, Denmark.
  • Christiansen D; Research Laboratory, Nordland Hospital, 8092 Bodø, Norway.
  • Mazarakis SMM; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Lojek N; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
  • Hansen P; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Gadeberg TAF; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Zarantonello A; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Laursen NS; Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus, Denmark.
  • Mollnes TE; Research Laboratory, Nordland Hospital, 8092 Bodø, Norway.
  • Johnson MB; K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, 9037 Tromsø, Norway.
  • Stevens B; Department of Immunology, Oslo University Hospital, University of Oslo, 0318 Oslo, Norway.
  • Thiel S; Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, 7491 Trondheim, Norway; and.
  • Andersen GR; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142.
J Immunol ; 205(8): 2287-2300, 2020 10 15.
Article in En | MEDLINE | ID: mdl-32938727
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement C3b / Complement Pathway, Alternative / Complement C5 Convertase, Alternative Pathway / Single-Domain Antibodies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Complement C3b / Complement Pathway, Alternative / Complement C5 Convertase, Alternative Pathway / Single-Domain Antibodies Limits: Animals / Humans Language: En Journal: J Immunol Year: 2020 Document type: Article