Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase.

Zhang, Yuhang; Corbett, Elizabeth; Wu, Shenping; Schatz, David G

Zhang, Yuhang; Corbett, Elizabeth; Wu, Shenping; Schatz, David G.

Affiliation

Zhang Y; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Corbett E; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Wu S; Department of Pharmacology, Yale School of Medicine West Haven, New Haven, CT, USA.
Schatz DG; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.

EMBO J ; 39(21): e105857, 2020 11 02.

Article in En | MEDLINE | ID: mdl-32945578

Subject(s)

DNA-Binding Proteins/chemistry; Evolution, Molecular; Homeodomain Proteins/chemistry; Recombinases/chemistry; Animals; Cryoelectron Microscopy; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; HMGB1 Protein/chemistry; HMGB1 Protein/genetics; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; Models, Molecular; Nuclear Proteins; Protein Conformation; Recombinases/genetics; Recombination, Genetic; Transposases/chemistry; Transposases/genetics; Transposases/metabolism; Vertebrates

Key words

DNA bending; V(D)J recombination; evolution; recombination-activating gene; transposition

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Homeodomain Proteins / Evolution, Molecular / Recombinases / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: EMBO J Year: 2020 Document type: Article

Fulltext

XML

PubMed Links

Search on Google