Efficient Synthesis of Cannabigerol, Grifolin, and Piperogalin via Alumina-Promoted Allylation.
J Nat Prod
; 83(9): 2587-2591, 2020 09 25.
Article
in En
| MEDLINE
| ID: mdl-32972142
ABSTRACT
The synthesis of three phenolic natural products has been accomplished with unprecedented efficiency using a new alumina-promoted regioselective aromatic allylation reaction. Cannabigerol and grifolin were prepared in one step from the inexpensive 5-alkyl-resorcinols olivetol and orcinol. Piperogalin was synthesized, for the first time, via two sequential allylations of orcinol with geraniol and prenol.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Resorcinols
/
Cannabinoids
/
Aluminum Oxide
Language:
En
Journal:
J Nat Prod
Year:
2020
Document type:
Article