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CYP-associated drug-drug interactions: A mission accomplished?
Pelkonen, Olavi; Hakkola, Jukka; Hukkanen, Janne; Turpeinen, Miia.
Affiliation
  • Pelkonen O; Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, Aapistie 5 B (POB5000), N90014, Oulu, Finland. olavi.pelkonen@oulu.fi.
  • Hakkola J; Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, Aapistie 5 B (POB5000), N90014, Oulu, Finland.
  • Hukkanen J; Biocenter Oulu, University of Oulu, Oulu, Finland.
  • Turpeinen M; Medical Research Center Oulu, University of Oulu, Oulu University Hospital, Oulu, Finland.
Arch Toxicol ; 94(11): 3931-3934, 2020 11.
Article in En | MEDLINE | ID: mdl-33025068
ABSTRACT
On the basis of official Finnish Medicines Authority (Fimea)-approved drug monographs, less than half of the approved small-molecule drugs between 2007 and 2016 were substrates, inhibitors or inducers of CYP enzymes, predominantly of CYP3A4. No significant unexpected, life-threatening, CYP-associated drug-drug interactions (CYP-DDIs) of newly approved drug entities have been observed in the last 10-15 years. The present analysis seems to suggest that tools to study and predict potentially significant CYP-DDIs are working and efficient.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Interactions / Cytochrome P-450 CYP3A / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors Type of study: Risk_factors_studies Limits: Animals / Humans Country/Region as subject: Europa Language: En Journal: Arch Toxicol Year: 2020 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Interactions / Cytochrome P-450 CYP3A / Cytochrome P-450 CYP3A Inducers / Cytochrome P-450 CYP3A Inhibitors Type of study: Risk_factors_studies Limits: Animals / Humans Country/Region as subject: Europa Language: En Journal: Arch Toxicol Year: 2020 Document type: Article