Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering.
Biomolecules
; 10(10)2020 10 07.
Article
in En
| MEDLINE
| ID: mdl-33036467
The ability of the cells to sense mechanical cues is an integral component of "social" cell behavior inside tissues with a complex architecture. Through "mechanosensation" cells are in fact able to decrypt motion, geometries and physical information of surrounding cells and extracellular matrices by activating intracellular pathways converging onto gene expression circuitries controlling cell and tissue homeostasis. Additionally, only recently cell mechanosensation has been integrated systematically as a crucial element in tissue pathophysiology. In the present review, we highlight some of the current efforts to assess the relevance of mechanical sensing into pathology modeling and manufacturing criteria for a next generation of cardiovascular tissue implants.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cardiovascular System
/
Tissue Engineering
/
Mechanotransduction, Cellular
/
Extracellular Matrix
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomolecules
Year:
2020
Document type:
Article