TRIM59 suppresses NO production by promoting the binding of PIAS1 and STAT1 in macrophages.

Su, Xiaomin; Zhang, Qianjing; Yue, Jianmei; Wang, Yachen; Zhang, Yuan; Yang, Rongcun

Su, Xiaomin; Zhang, Qianjing; Yue, Jianmei; Wang, Yachen; Zhang, Yuan; Yang, Rongcun.

Affiliation

Su X; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China; Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China. Electronic address
Zhang Q; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China; Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.
Yue J; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China; Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.
Wang Y; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China.
Zhang Y; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China; Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.
Yang R; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China; Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China. Electronic address

Int Immunopharmacol ; 89(Pt A): 107030, 2020 Dec.

Article in En | MEDLINE | ID: mdl-33045573

Subject(s)

Intracellular Signaling Peptides and Proteins/metabolism; Macrophages/metabolism; Nitric Oxide/metabolism; Protein Inhibitors of Activated STAT/metabolism; STAT1 Transcription Factor/metabolism; Tripartite Motif Proteins/metabolism; Animals; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Down-Regulation; Intracellular Signaling Peptides and Proteins/genetics; Janus Kinase 2/metabolism; Lipopolysaccharides/pharmacology; Macrophages/drug effects; Macrophages/transplantation; Melanoma, Experimental/metabolism; Melanoma, Experimental/pathology; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type II/genetics; Nitric Oxide Synthase Type II/metabolism; Phosphorylation; Protein Binding; Protein Inhibitors of Activated STAT/genetics; RAW 264.7 Cells; Tripartite Motif Proteins/genetics; Tumor Burden; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism; Tumor-Associated Macrophages/metabolism; Tumor-Associated Macrophages/transplantation

Key words

COX2; JAK2-STAT1 pathways; Macrophage; Melanoma; TRIM59; iNOS

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Intracellular Signaling Peptides and Proteins / STAT1 Transcription Factor / Protein Inhibitors of Activated STAT / Tripartite Motif Proteins / Macrophages / Nitric Oxide Limits: Animals Language: En Journal: Int Immunopharmacol Year: 2020 Document type: Article

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