Rearrangement of N-Terminal &#945;-Helices of <i>Bacillus thuringiensis</i> Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity.

Pacheco, Sabino; Quiliche, Jean Piere Jesus; Gómez, Isabel; Sánchez, Jorge; Soberón, Mario; Bravo, Alejandra

Rearrangement of N-Terminal α-Helices of Bacillus thuringiensis Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity.

Pacheco, Sabino; Quiliche, Jean Piere Jesus; Gómez, Isabel; Sánchez, Jorge; Soberón, Mario; Bravo, Alejandra.

Affiliation

Pacheco S; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos 62250, Mexico.
Quiliche JPJ; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos 62250, Mexico.
Gómez I; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos 62250, Mexico.
Sánchez J; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos 62250, Mexico.
Soberón M; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos 62250, Mexico.
Bravo A; Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos 62250, Mexico.

Toxins (Basel) ; 12(10)2020 10 08.

Article in En | MEDLINE | ID: mdl-33049917

Subject(s)

Bacillus cereus/metabolism; Bacillus thuringiensis Toxins/pharmacology; Endotoxins/pharmacology; Hemolysin Proteins/pharmacology; Manduca/drug effects; Pest Control, Biological; Animals; Bacillus cereus/genetics; Bacillus thuringiensis Toxins/chemistry; Bacillus thuringiensis Toxins/genetics; Bacillus thuringiensis Toxins/metabolism; Endotoxins/chemistry; Endotoxins/genetics; Endotoxins/metabolism; Hemolysin Proteins/chemistry; Hemolysin Proteins/genetics; Hemolysin Proteins/metabolism; Manduca/metabolism; Microvilli/drug effects; Microvilli/metabolism; Mutation; Protein Conformation, alpha-Helical; Protein Multimerization; Structure-Activity Relationship

Key words

Bacillus thuringiensis; Cry1ab toxin; Föster Resonance Energy Transfer (FRET); disulfide bridges; oligomer assembly

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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 Database: MEDLINE Main subject: Bacillus cereus / Pest Control, Biological / Manduca / Endotoxins / Bacillus thuringiensis Toxins / Hemolysin Proteins Limits: Animals Language: En Journal: Toxins (Basel) Year: 2020 Document type: Article

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