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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.
Wrobel, Antoni G; Benton, Donald J; Hussain, Saira; Harvey, Ruth; Martin, Stephen R; Roustan, Chloë; Rosenthal, Peter B; Skehel, John J; Gamblin, Steven J.
Affiliation
  • Wrobel AG; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK. antoni.wrobel@crick.ac.uk.
  • Benton DJ; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK. donald.benton@crick.ac.uk.
  • Hussain S; Worldwide Influenza Centre, Francis Crick Institute, NW1 1AT, London, UK.
  • Harvey R; Worldwide Influenza Centre, Francis Crick Institute, NW1 1AT, London, UK.
  • Martin SR; Structural Biology Science Technology Platform, Francis Crick Institute, NW1 1AT, London, UK.
  • Roustan C; Structural Biology Science Technology Platform, Francis Crick Institute, NW1 1AT, London, UK.
  • Rosenthal PB; Structural Biology of Cells and Viruses Laboratory, Francis Crick Institute, NW1 1AT, London, UK.
  • Skehel JJ; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK.
  • Gamblin SJ; Structural Biology of Disease Processes Laboratory, Francis Crick Institute, NW1 1AT, London, UK. steven.gamblin@crick.ac.uk.
Nat Commun ; 11(1): 5337, 2020 10 21.
Article in En | MEDLINE | ID: mdl-33087721
The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Binding Sites, Antibody / Spike Glycoprotein, Coronavirus / Betacoronavirus / Antibodies, Monoclonal / Antibodies, Viral Limits: Animals / Humans Language: En Journal: Nat Commun Year: 2020 Document type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Binding Sites, Antibody / Spike Glycoprotein, Coronavirus / Betacoronavirus / Antibodies, Monoclonal / Antibodies, Viral Limits: Animals / Humans Language: En Journal: Nat Commun Year: 2020 Document type: Article