Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling.
J Asian Nat Prod Res
; 23(6): 584-595, 2021 Jun.
Article
in En
| MEDLINE
| ID: mdl-33233968
ABSTRACT
Decursin, a coumarin compound isolated from Angelica gigas has been shown to possess multiple anti-tumor activities. But it's still little known about the effects associated with cervical cancer. To explore the anti-tumor role of decursin and gain insights into its underlying mechanisms, we analyzed proliferation in parallel with apoptosis and migration in HeLa cells. Our findings implied that decursin can provoke apoptosis, and inhibit cell proliferation, migration in HeLa cells. More importantly, decursin also inhibited the tumor growth in vivo. The mechanisms may be associated with the regulation of Akt activation, with implications for novel therapeutic strategies on cervical cancer.[Formula see text].
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzopyrans
/
Butyrates
/
Signal Transduction
/
Uterine Cervical Neoplasms
Limits:
Female
/
Humans
Language:
En
Journal:
J Asian Nat Prod Res
Year:
2021
Document type:
Article