SARS-CoV-2 immunochromatographic IgM/IgG rapid test in pregnancy: A false friend?
Ann Clin Biochem
; 58(2): 149-152, 2021 03.
Article
in En
| MEDLINE
| ID: mdl-33242972
ABSTRACT
BACKGROUND:
An increasing body of evidence has revealed that SARS-CoV-2 infection in pregnant women could increase the risk of adverse maternal and fetal outcomes. Careful monitoring of pregnancies with COVID-19 and measures to prevent neonatal infection are warranted. Therefore, rapid antibody tests have been suggested as an efficient screening tool during pregnancy. CASES We analysed the clinical performance during pregnancy of a rapid, lateral-flow immunochromatographic assay for qualitative detection of SARS-CoV-2 IgG/IgM antibodies. We performed a universal screening including 169 patients during their last trimester of pregnancy. We present a series of 14 patients with positive SARS-CoV-2 immunochromatographic assay rapid test result. Immunochromatographic assay results were always confirmed by chemiluminescent microparticle immunoassays for quantitative detection of SARS-CoV-2 IgG and IgM+IgA antibodies as the gold standard. We observed a positive predictive value of 50% and a false positive rate of 50% in pregnant women, involving a significantly lower diagnostic performance than reported in non-pregnant patients.DISCUSSION:
Our data suggest that although immunochromatographic assay rapid tests may be a fast and profitable screening tool for SARS-CoV-2 infection, they may have a high false positive rate and low positive predictive value in pregnant women. Therefore, immunochromatographic assay for qualitative detection of SARS-CoV-2 IgG/IgM antibodies must be verified by other test in pregnant patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications, Infectious
/
Immunoglobulin G
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Immunoglobulin M
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COVID-19 Serological Testing
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SARS-CoV-2
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COVID-19
/
Antibodies, Viral
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Qualitative_research
Limits:
Adult
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Female
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Humans
/
Pregnancy
Language:
En
Journal:
Ann Clin Biochem
Year:
2021
Document type:
Article