Presumptive Lornoxicam Intoxication in Four Dogs.
Top Companion Anim Med
; 42: 100502, 2021 Mar.
Article
in En
| MEDLINE
| ID: mdl-33249243
ABSTRACT
Lornoxicam is a nonsteroidal anti-inflammatory drug extensively used in human medicine, which is not approved for canine use. Lornoxicam intoxication has been rarely reported in dogs. Four dogs of various breeds, aged 7 months to 10 years, were admitted with a recent history of melena, anorexia and depression, occurring 1-4 days after the ingestion of lornoxicam (dose range 0.53-2.7 [median 1.17] mg/kg). No clinically relevant comorbidities were documented, but low doses of prednisolone had been given in 3 of the dogs, in close temporal association with lornoxicam. Major clinical and clinicopathologic findings on admission included mucosal pallor, melena, depression, severe anemia, neutrophilic leucocytosis, and panhypoproteinemia. Perforated pyloric and duodenal ulcers were documented in 3 dogs by exploratory celiotomy or postmortem. Prolonged hospitalization (5-20 days) with extensive supportive care and multiple blood transfusions was required in 3 of the 4 dogs who survived to discharge. Lornoxicam ingestion may cause protracted and severe gastrointestinal tract injury and bleeding, blood loss anemia, panhypoproteinemia, and perforated gastrointestinal ulcers, associated with significant morbidity and mortality in dogs.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piroxicam
/
Anti-Inflammatory Agents, Non-Steroidal
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Digestive System
/
Dog Diseases
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Gastrointestinal Hemorrhage
/
Anemia
Limits:
Animals
Language:
En
Journal:
Top Companion Anim Med
Year:
2021
Document type:
Article