Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation.

Wen, Jiexia; Chang, Yumei; Huo, Shanshan; Li, Wenyan; Huang, Heling; Gao, Yunhuan; Lin, Hongyu; Zhang, Jianlou; Zhang, Yonghong; Zuo, Yuzhu; Cao, Xuebin; Zhong, Fei

Wen, Jiexia; Chang, Yumei; Huo, Shanshan; Li, Wenyan; Huang, Heling; Gao, Yunhuan; Lin, Hongyu; Zhang, Jianlou; Zhang, Yonghong; Zuo, Yuzhu; Cao, Xuebin; Zhong, Fei.

Affiliation

Wen J; College of Veterinary Medicine and College of Animal Science and Technology, Hebei Veterinary Biotechnology Innovation Center, Hebei Agricultural University, Baoding 071001, Hebei, China.
Chang Y; Department of Central Laboratory, First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei, China.
Huo S; Department of Cardiology, 252 Hospital of Chinese PLA, Baoding 071000, Hebei, China.
Li W; College of Veterinary Medicine and College of Animal Science and Technology, Hebei Veterinary Biotechnology Innovation Center, Hebei Agricultural University, Baoding 071001, Hebei, China.
Huang H; College of Veterinary Medicine and College of Animal Science and Technology, Hebei Veterinary Biotechnology Innovation Center, Hebei Agricultural University, Baoding 071001, Hebei, China.
Gao Y; Department of Biology, College of Basic Medicine, Hebei University, Baoding 071000, Hebei, China.
Lin H; Department of Cardiology, 252 Hospital of Chinese PLA, Baoding 071000, Hebei, China.
Zhang J; College of Veterinary Medicine and College of Animal Science and Technology, Hebei Veterinary Biotechnology Innovation Center, Hebei Agricultural University, Baoding 071001, Hebei, China.
Zhang Y; Department of Cardiology, 252 Hospital of Chinese PLA, Baoding 071000, Hebei, China.
Zuo Y; College of Veterinary Medicine and College of Animal Science and Technology, Hebei Veterinary Biotechnology Innovation Center, Hebei Agricultural University, Baoding 071001, Hebei, China.
Cao X; College of Veterinary Medicine and College of Animal Science and Technology, Hebei Veterinary Biotechnology Innovation Center, Hebei Agricultural University, Baoding 071001, Hebei, China.
Zhong F; College of Veterinary Medicine and College of Animal Science and Technology, Hebei Veterinary Biotechnology Innovation Center, Hebei Agricultural University, Baoding 071001, Hebei, China.

Aging (Albany NY) ; 13(1): 910-932, 2020 11 16.

Article in En | MEDLINE | ID: mdl-33290264

Subject(s)

Abietanes/pharmacology; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Aorta/drug effects; Atherosclerosis/metabolism; Inflammasomes/drug effects; Macrophages/drug effects; NLR Family, Pyrin Domain-Containing 3 Protein/drug effects; Animals; Aorta/metabolism; Aorta/pathology; Atherosclerosis/pathology; CD36 Antigens/drug effects; CD36 Antigens/metabolism; Diet, High-Fat; Inflammasomes/metabolism; Lipoproteins, LDL/drug effects; Lipoproteins, LDL/metabolism; Macrophages/metabolism; Mice; Mice, Knockout, ApoE; NF-kappa B/drug effects; NF-kappa B/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein/genetics; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Scavenger Receptors, Class E/drug effects; Scavenger Receptors, Class E/metabolism

Key words

LOX-1; atherosclerosis; inflammasome; oxidized LDL; tanshinone IIA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Anti-Inflammatory Agents, Non-Steroidal / Abietanes / Atherosclerosis / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / Macrophages Limits: Animals Language: En Journal: Aging (Albany NY) Year: 2020 Document type: Article

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