Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1&#945;-NF-&#954;B Crosstalk In Vitro and In Vivo.

Chang, Sukkum Ngullie; Dey, Debasish Kumar; Oh, Seong Taek; Kong, Won Ho; Cho, Kiu Hyung; Al-Olayan, Ebtesam M; Hwang, Buyng Su; Kang, Sun Chul; Park, Jae Gyu

Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo.

Chang, Sukkum Ngullie; Dey, Debasish Kumar; Oh, Seong Taek; Kong, Won Ho; Cho, Kiu Hyung; Al-Olayan, Ebtesam M; Hwang, Buyng Su; Kang, Sun Chul; Park, Jae Gyu.

Affiliation

Chang SN; Department of Biotechnology, Daegu University, Gyeongsan 38453, Korea.
Dey DK; Advanced Bio Convergence Center, Pohang Technopark Foundation, Pohang 37668, Gyeongbuk, Korea.
Oh ST; Department of Biotechnology, Daegu University, Gyeongsan 38453, Korea.
Kong WH; Advanced Bio Convergence Center, Pohang Technopark Foundation, Pohang 37668, Gyeongbuk, Korea.
Cho KH; Okinawa Research Center Co. Ltd., 13-33, Suzaki, Uruma-si, Okinawa Ken 904-2234, Japan.
Al-Olayan EM; Advanced Bio Convergence Center, Pohang Technopark Foundation, Pohang 37668, Gyeongbuk, Korea.
Hwang BS; Research Group, Gyeongbuk Institute for Bio Industry (GIB), Andong 36728, Korea.
Kang SC; Department of Zoology, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Park JG; Nakdonggang National Institute of Biological Resources, Sangju 37242, Korea.

Int J Mol Sci ; 21(23)2020 Dec 04.

Article in En | MEDLINE | ID: mdl-33291656

Subject(s)

Flavones/pharmacology; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; NF-kappa B/metabolism; Signal Transduction/drug effects; Tetradecanoylphorbol Acetate/adverse effects; Animals; Antioxidants; Biomarkers; Cell Line, Transformed; Congenital Abnormalities; Embryonic Development/genetics; Epidermis; Humans; Inflammation/etiology; Inflammation/metabolism; Keratinocytes/metabolism; Lipid Peroxidation; Onions/drug effects; Onions/genetics; Onions/metabolism; Oxidative Stress; Reactive Oxygen Species/metabolism; Zebrafish

Key words

allium cepa test; hypoxia-inducible factor 1-alpha (HIF-1α); inflammation; nuclear factor kappa-light-chain-enhancer of activated b cells (NF-κb); phorbol 12-myristate 13-acetate (PMA); tangeretin (TAN); zebrafish embryotoxicity test

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetradecanoylphorbol Acetate / Signal Transduction / NF-kappa B / Flavones / Hypoxia-Inducible Factor 1, alpha Subunit Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2020 Document type: Article

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