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Evaluation of Hepatitis B Reactivation Among Patients With Chronic Myeloid Leukemia Treated With Tyrosine Kinase Inhibitors.
Atteya, Asmaa; Ahmad, Aiman; Daghstani, Dima; Mushtaq, Kamran; Yassin, Mohamed A.
Affiliation
  • Atteya A; National Center for Cancer Care and Research, Doha, Qatar.
  • Ahmad A; National Center for Cancer Care and Research, Doha, Qatar.
  • Daghstani D; Department of Pharmacy, National Center for Cancer Care and Research, Doha, Qatar.
  • Mushtaq K; Gastroenterology Department, Hamad Medical Corporation, Doha, Qatar.
  • Yassin MA; Gastroenterology Department, Hamad Medical Corporation, Doha, Qatar.
Cancer Control ; 27(1): 1073274820976594, 2020.
Article in En | MEDLINE | ID: mdl-33297765
ABSTRACT
Hepatitis B reactivation (HBVr) in cancer patients is a well-established complication due to chemotherapy-induced immunosuppression. Studies have reported HBVr associated with immunosuppressive medications, such as rituximab, methotrexate, and high dose steroids. There are different risks for different types of chemotherapy with rituximab carrying one of the highest risks for hepatitis B reactivation. Tyrosine kinase inhibitors (TKIs) are the standard of care in patients with chronic myeloid leukemia (CML). The risk of HBVr in chronic myeloid leukemia has been reported in many studies, but to this date, there are no clear guidelines or recommendations regarding screening and monitoring of HBV in CML patients receiving TKIs. We conducted this review to identify the risk of HBVr in patients with CML who are treated with tyrosine kinase inhibitors. We recommend testing for HBV status in patients who are to be treated with TKIs and to consider giving prophylaxis in those who are positive for HBsAg at baseline. More studies are needed to assess the risk of reactivation in patients with Hepatitis B core antibody positive receiving TKIs. Currently, monitoring such patients for reactivation may be the best strategy.
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 / 4_TD Database: MEDLINE Main subject: Virus Activation / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Hepatitis B virus / Hepatitis B, Chronic / Protein Kinase Inhibitors Type of study: Guideline / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Cancer Control Year: 2020 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 / 2_ODS3 / 4_TD Database: MEDLINE Main subject: Virus Activation / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Hepatitis B virus / Hepatitis B, Chronic / Protein Kinase Inhibitors Type of study: Guideline / Prognostic_studies / Screening_studies Limits: Humans Language: En Journal: Cancer Control Year: 2020 Document type: Article