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Exercise and crocin prevent adolescent-stress induced impairment of spatial navigation and dendritic retraction in the hippocampal CA3 area in adult male rats.
Ghalandari-Shamami, Mohadeseh; Nourizade, Shahla; Barati, Mehdi; Yousefi, Behpour; Pashayi, Mehrnush; Ali Vafaei, Abbas; Kokhaei, Parviz; Rashidy-Pour, Ali.
Affiliation
  • Ghalandari-Shamami M; Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
  • Nourizade S; Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
  • Barati M; Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Yousefi B; Department of Anatomical Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
  • Pashayi M; Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran.
  • Ali Vafaei A; Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
  • Kokhaei P; Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran.
  • Rashidy-Pour A; Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran. Electronic address: rashidy-pour@semums.ac.ir.
Brain Res ; 1754: 147274, 2021 03 01.
Article in En | MEDLINE | ID: mdl-33422526
Adolescent chronic stress has been shown to induce functional, biochemical and morphological modifications of the hippocampus, leading to stress-related disorders in adulthood. The present study investigated the effects of exercise, crocin and their combination on spatial learning and memory impairment and dendritic retraction of the CA3 pyramidal neurons induced by chronic adolescent stress in adult male rats. Rats were exposed to restraint stress 2 h/day for 10 days during postnatal days (PNDs) 30-40. Following this period, separate groups of animals were treated with crocin (25 and 50 mg/kg), exposed to running wheel, and or received the combined treatment during PNDs 41-55. Following the interventions, plasma levels of corticosterone, spatial learning and memory, apical dendritic length of CA3 pyramidal neurons and BDNF levels in the CA3 area were assessed. Findings showed that adolescent stress significantly increased corticosterone levels and caused a tendency to reduce CA3 BDNF levels. Adolescent stress also impaired spatial learning and memory, and retracted apical dendritic length of CA3 pyramidal neurons. Crocin, voluntary exercise, and their combination recovered stress-induced spatial learning and impairment and CA3 pyramidal neurons dendritic length retraction. All treatments also reduced significantly corticosterone levels and enhanced CA3 BDNF levels in the stress groups. Finally, these treatments even increased apical dendritic length of CA3 pyramidal neurons in the non-stress groups. These findings indicate that detrimental effects of adolescent stress on cognitive function and hippocampal morphology in adulthood could be restored by early interventions with physical activity and crocin treatment during adolescent period.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Physical Conditioning, Animal / Carotenoids / Dendrites / Hippocampus Limits: Animals Language: En Journal: Brain Res Year: 2021 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Physical Conditioning, Animal / Carotenoids / Dendrites / Hippocampus Limits: Animals Language: En Journal: Brain Res Year: 2021 Document type: Article