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Complete recovery from COVID-19 of a kidney-pancreas transplant recipient: potential benefit from everolimus?
Heron, Vanessa C; Bach, Cindy-Anne T; Holmes, Natasha E; Whitlam, John B.
Affiliation
  • Heron VC; Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia.
  • Bach CT; Department of General Medicine, Austin Health, Heidelberg, Victoria, Australia.
  • Holmes NE; Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
  • Whitlam JB; Department of Nephrology, Austin Health, Heidelberg, Victoria, Australia john.whitlam@austin.org.au.
BMJ Case Rep ; 14(1)2021 Jan 11.
Article in En | MEDLINE | ID: mdl-33431539
We present a kidney-pancreas transplant recipient who achieved complete recovery from COVID-19. A 45-year-old patient with T3 paraplegia underwent kidney-pancreas transplantation 18 years ago, followed by a subsequent kidney transplant 9 years ago, and presented with fever, hypoxia and hypotension after exposure to two confirmed cases of COVID-19. History of solid organ transplant, pre-existing renal impairment, asthma and an elevated D-dimer were identified as established risk factors for severe COVID-19. Supportive management was provided, baseline immunosuppression with everolimus was continued, and oral prednisolone was increased. A complete recovery was observed. Given the favourable outcome despite risk factors for severe COVID-19, we identify and review the potential mitigating roles of immunosuppression and mammalian target of rapamycin (mTOR) inhibitors in this disease. Further investigation is required to establish whether mTOR inhibitors could be used as therapeutic agents to treat COVID-19, or as alternative immunosuppression implemented early in the COVID-19 disease course.
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Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 4_TD Database: MEDLINE Main subject: Paraplegia / Kidney Transplantation / Pancreas Transplantation / COVID-19 / Glucocorticoids / Graft Rejection / Immunosuppressive Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans / Male / Middle aged Language: En Journal: BMJ Case Rep Year: 2021 Document type: Article

Full text: 1 Collection: 01-internacional Health context: 2_ODS3 / 4_TD Database: MEDLINE Main subject: Paraplegia / Kidney Transplantation / Pancreas Transplantation / COVID-19 / Glucocorticoids / Graft Rejection / Immunosuppressive Agents Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans / Male / Middle aged Language: En Journal: BMJ Case Rep Year: 2021 Document type: Article