Remodeling nanoDESI Platform with Ion Mobility Spectrometry to Expand Protein Coverage in Cancerous Tissue.

Chen, Chih-Lin; Kuo, Ting-Hao; Chung, Hsin-Hsiang; Huang, Penghsuan; Lin, Li-En; Hsu, Cheng-Chih

Chen, Chih-Lin; Kuo, Ting-Hao; Chung, Hsin-Hsiang; Huang, Penghsuan; Lin, Li-En; Hsu, Cheng-Chih.

Affiliation

Chen CL; Department of Chemistry, National Taiwan University, Taipei 106216, Taiwan.
Kuo TH; Department of Chemistry, National Taiwan University, Taipei 106216, Taiwan.
Chung HH; Department of Chemistry, National Taiwan University, Taipei 106216, Taiwan.
Huang P; Department of Chemistry, National Taiwan University, Taipei 106216, Taiwan.
Lin LE; Department of Chemistry, National Taiwan University, Taipei 106216, Taiwan.
Hsu CC; Department of Chemistry, National Taiwan University, Taipei 106216, Taiwan.

J Am Soc Mass Spectrom ; 32(3): 653-660, 2021 Mar 03.

Article in En | MEDLINE | ID: mdl-33507077

Subject(s)

Ion Mobility Spectrometry/instrumentation; Neoplasms/diagnosis; Proteins/analysis; Spectrometry, Mass, Electrospray Ionization/instrumentation; Animals; Humans; Melanoma/chemistry; Melanoma/diagnosis; Mice; Molecular Imaging/methods; Neoplasms/chemistry; Skin Neoplasms/chemistry; Skin Neoplasms/diagnosis

Key words

FAIMS; cancer diagnosis; nanoDESI; pneumatic-assisted nanoDESI; protein MS imaging; top-down tandem mass spectrometry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Spectrometry, Mass, Electrospray Ionization / Ion Mobility Spectrometry / Neoplasms Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Am Soc Mass Spectrom Year: 2021 Document type: Article

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