KMU-1170, a Novel Multi-Protein Kinase Inhibitor, Suppresses Inflammatory Signal Transduction in THP-1 Cells and Human Osteoarthritic Fibroblast-Like Synoviocytes by Suppressing Activation of NF-&#954;B and NLRP3 Inflammasome Signaling Pathway.

Baek, Hye Suk; Hong, Victor Sukbong; Kim, Sang Hyon; Lee, Jinho; Kim, Shin

KMU-1170, a Novel Multi-Protein Kinase Inhibitor, Suppresses Inflammatory Signal Transduction in THP-1 Cells and Human Osteoarthritic Fibroblast-Like Synoviocytes by Suppressing Activation of NF-κB and NLRP3 Inflammasome Signaling Pathway.

Baek, Hye Suk; Hong, Victor Sukbong; Kim, Sang Hyon; Lee, Jinho; Kim, Shin.

Affiliation

Baek HS; Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Korea.
Hong VS; Department of Chemistry, Keimyung University, Daegu 42601, Korea.
Kim SH; Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keimyung University, Daegu 42601, Korea.
Lee J; Institute of Medical Science, Keimyung University, Daegu 42601, Korea.
Kim S; Department of Chemistry, Keimyung University, Daegu 42601, Korea.

Int J Mol Sci ; 22(3)2021 Jan 26.

Article in En | MEDLINE | ID: mdl-33530480

Subject(s)

Inflammasomes/metabolism; NF-kappa B/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Protein Kinase Inhibitors/pharmacology; Signal Transduction/drug effects; Synoviocytes/drug effects; Synoviocytes/metabolism; Anti-Inflammatory Agents/chemistry; Anti-Inflammatory Agents/pharmacology; Cyclooxygenase 2/metabolism; Cytokines/metabolism; Humans; Inflammation/drug therapy; Inflammation/etiology; Inflammation/metabolism; Inflammation Mediators/metabolism; Lipopolysaccharides/adverse effects; Nitric Oxide Synthase Type II/metabolism; Osteoarthritis/etiology; Osteoarthritis/metabolism; Osteoarthritis/pathology; Phosphorylation; Protein Kinase Inhibitors/chemistry; THP-1 Cells

Key words

KMU-1170; NF-κB; NLRP3 inflammasome; fibroblast-like synoviocyte; inflammation; lipopolysaccharide; osteoarthritis; protein kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / NF-kappa B / Protein Kinase Inhibitors / Inflammasomes / Synoviocytes / NLR Family, Pyrin Domain-Containing 3 Protein Type of study: Etiology_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article

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