Changes in epigenetic profiles throughout early childhood and their relationship to the response to pneumococcal vaccination.
Clin Epigenetics
; 13(1): 29, 2021 02 04.
Article
in En
| MEDLINE
| ID: mdl-33541404
ABSTRACT
BACKGROUND:
Pneumococcal infections are a major cause of morbidity and mortality in young children and immaturity of the immune system partly underlies poor vaccine responses seen in the young. Emerging evidence suggests a key role for epigenetics in the maturation and regulation of the immune system in health and disease. The study aimed to investigate epigenetic changes in early life and to understand the relationship between the epigenome and antigen-specific antibody responses to pneumococcal vaccination.METHODS:
The epigenetic profiles from 24 healthy children were analyzed at 12 months prior to a booster dose of the 13-valent pneumococcal conjugate vaccine (PCV-13), and at 24 months of age, using the Illumina Methylation 450 K assay and assessed for differences over time and between high and low vaccine responders.RESULTS:
Our analysis revealed 721 significantly differentially methylated positions between 12 and 24 months (FDR < 0.01), with significant enrichment in pathways involved in the regulation of cell-cell adhesion and T cell activation. Comparing high and low vaccine responders, we identified differentially methylated CpG sites (P value < 0.01) associated with HLA-DPB1 and IL6.CONCLUSION:
These data imply that epigenetic changes that occur during early childhood may be associated with antigen-specific antibody responses to pneumococcal vaccines.Key words
Full text:
1
Collection:
01-internacional
Health context:
2_ODS3
/
4_TD
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Database:
MEDLINE
Main subject:
Pneumococcal Infections
/
Pneumococcal Vaccines
/
Immune System
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child, preschool
/
Female
/
Humans
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Infant
/
Male
Language:
En
Journal:
Clin Epigenetics
Year:
2021
Document type:
Article