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Does biomarker use in oncology improve clinical trial failure risk? A large-scale analysis.
Parker, Jayson L; Kuzulugil, Sebnem S; Pereverzev, Kirill; Mac, Stephen; Lopes, Gilberto; Shah, Zain; Weerasinghe, Ashini; Rubinger, Daniel; Falconi, Adam; Bener, Ayse; Caglayan, Bora; Tangri, Rohan; Mitsakakis, Nicholas.
Affiliation
  • Parker JL; Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
  • Kuzulugil SS; St Michael's Hospital, Toronto, ON, Canada.
  • Pereverzev K; Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
  • Mac S; Institute of Health Policy, Management and Evaluation, University of Toronto, Mississauga, ON, Canada.
  • Lopes G; University of Miami, Miller School of Medicine, Coral Gables, FL, USA.
  • Shah Z; Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
  • Weerasinghe A; Prevention and Cancer Control, Cancer Care Ontario, Toronto, ON, Canada.
  • Rubinger D; Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
  • Falconi A; Department of Pharmacy, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
  • Bener A; Mechanical and Industrial Engineering, Ryerson University, Toronto, ON, Canada.
  • Caglayan B; Mechanical and Industrial Engineering, Ryerson University, Toronto, ON, Canada.
  • Tangri R; Department of Biology, University of Toronto Mississauga, Mississauga, ON, Canada.
  • Mitsakakis N; Institute of Health Policy, Management and Evaluation, and Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Cancer Med ; 10(6): 1955-1963, 2021 03.
Article in En | MEDLINE | ID: mdl-33620160
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Biomarkers, Tumor / Clinical Trials as Topic / Markov Chains / Drug Approval / Neoplasms / Antineoplastic Agents Type of study: Clinical_trials / Etiology_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Language: En Journal: Cancer Med Year: 2021 Document type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Health context: 1_ASSA2030 Database: MEDLINE Main subject: Biomarkers, Tumor / Clinical Trials as Topic / Markov Chains / Drug Approval / Neoplasms / Antineoplastic Agents Type of study: Clinical_trials / Etiology_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies Language: En Journal: Cancer Med Year: 2021 Document type: Article