Effect of triclosan on the pathogenesis of allergic diseases among children.
J Expo Sci Environ Epidemiol
; 32(1): 60-68, 2022 01.
Article
in En
| MEDLINE
| ID: mdl-33654271
ABSTRACT
BACKGROUND:
Few studies have assessed associations between allergic diseases and antibacterial agents in Taiwanese children.OBJECTIVE:
This study aimed to investigate the association of triclosan (TCS) exposure with allergic diseases among preschoolers, disease-specific IgE titers, and a child's sex.METHODS:
Pediatric data were obtained from the Childhood Environment and Allergic Diseases Study (CEAS; 2010) cohort, and their urine and blood samples were used to analyze TCS and IgE concentrations (age 3 group). Three years later, clinical data were obtained again from the age 3 group (age 6 group). Correlations of TCS levels at ages 3 and 6 years with IgE levels and allergic diseases were evaluated.RESULTS:
The TCS levels were higher at age 3 than at age 6 (geometric mean, 1.05 ng/ml vs 0.37 ng/ml). TCS levels were positively correlated with serum IgE levels at ages 3 and 6 years. Asthma and atopic dermatitis were significantly associated with TCS (adjusted OR 1.14, 95% confidence interval [CI] 1.01-1.29; OR 1.22, 95% CI 1.05-1.41). Sex-stratified analysis revealed that TCS levels were positively correlated with IgE levels among boys in the age 6 group and significantly associated with asthma, allergic rhinitis, and atopic dermatitis among boys.SIGNIFICANCE:
TCS exposure is associated with IgE levels and a potentially high risk of pediatric atopic disorders.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Triclosan
/
Dermatitis, Atopic
/
Hypersensitivity
Type of study:
Etiology_studies
Limits:
Child
/
Child, preschool
/
Humans
/
Male
Language:
En
Journal:
J Expo Sci Environ Epidemiol
Year:
2022
Document type:
Article